

Tom Kenny as Grob, Gardener #1 and Martian Guard #2.Jess Harnell as Buzz Blister, Martian General and Worker #3.Brad Garrett as Commander Bristle and Martian Guard #3.Corey Burton as Martian Scientist, Court Attendant and Eyes At Gate.In the epilogue, Biff and Buzz are cleaning the mess as punishment for lying that there is no life on Mars they soon start to argue and fight about it as a horrified Tom is still being pursued by the Spike-controlled Invince-a-tron into the sunset. Peep flies back to Earth with the flying saucer and rescues Jerry, but leaves Tom behind to be chased by the Spike-controlled Invince-a-tron. Before they could even drive it, however, they are attacked once again by a newly repaired Invince-a-tron controlled by Spike, who vows revenge on them for the destruction of his bone. President (also voiced by Jeff Bennett) for saving Earth from being destroyed by the Invince-a-tron. In the aftermath, Tom and Jerry are rewarded with a Hummer by the U.S. Tom, Jerry and Peep ultimately foil the Invince-a-tron by using a bone to get Spike (also voiced by Frank Welker) into his brain and make it malfunction, destroying it. They manage to stop them, but a gigantic orange vacuum cleaner robot named the “Invince-a-tron” eventually arrives on Earth and begins to suck everyone up with its vacuum. After much calamity and a discovery that Jerry is not the Great Gloop, Tom, Jerry and Peep hijack a flying saucer (UFO) so that they can get back to Earth and warn everyone about a potential attack by the martians. A green female alien named Peep (voiced by Kathryn Fiore) along with an alien dog Ubu (voiced by Frank Welker) and two more martians (voiced by Jeff Bennett and Tom Kenny) arrive to which Jerry is then taken to the martians' lair where he is mistaken for the “Great Gloop”. During the chase, the duo land onto a rocket ending up at Mars where Tom and Jerry are left behind. Soon, the staff tries to catch Jerry, but figuring that only Tom can catch him, they bring him back to the base and give him a mission to eliminate Jerry. During the testing of dehydrated food, Jerry knocks over a cup in the process, resulting in the food going all over the place in an explosion. In the process, Tom and Jerry are caught during the speech (first misunderstood as aliens due to Tom getting hit by green paint backstage) and the staff try to capture them, but only Tom is caught and thrown out.

Tom (voiced by Bill Kopp) chases Jerry (voiced by Dee Bradley Baker) as usual from their house and across town until they arrive at the "International Space Place", where astronauts Buzz Blister (voiced by Jess Harnell) and Biff Buzzard (voiced by Billy West) are heading to Mars.
